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The targeting construct contains a loxP site inserted in the intron 5' to the last exon and a loxP-flanked neomycin cassette inserted 3' to the last exon. Germline Cre-mediated recombination removed the floxed neo cassette leaving the last exon floxed. The last exon encodes the ligand binding domain and all of the 3' untranslated region. (J:64792)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
