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EN
A construct consisting of a floxed neo cassette, tTA site, a CMV promoter with a tetracycline responsive element, a human APOE_i3 cDNA, an IRES site and an EGFP gene, was inserted via homologous recombination. In the absence of Cre-mediated recombination the human protein is not expressed. Following Cre-mediated recombination the human protein is expressed and this expression may be suppressed with the addition of doxycycline. (J:256115)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
