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An alanine substitution for serine at amino acid 368 (AGC to GCT) at a protein kinase C (PKC) phosphorylation site was introduced in exon II and a floxed PGK-Neo cassette was inserted upstream of exon II. Western blot analysis of whole heart lysates showed that the protein expression level is reduced by more than 70%. (J:253159)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
