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CRISPR/Cas9 mediated recombination deleted 21 of the 22 amino acid residues in the LRR9 domain while maintaining the open reading frame of the gene. Western blot analysis indicates that overall expression of the gene is not altered. Immunoprecipitation analysis confirmed that binding to Nlgn2 is disrupted by this mutation. (J:256117)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
