A 6xMyc epitope tag was inserted in exon 2 adjacent to the C-terminus of the signal sequence between the codons for L26 and L27 and a floxed neo cassette was inserted 510 bp downstream of exon 2 via homologous recombination. Cre-mediated recombination removed the neo cassette. (J:256151)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count