The targeting vector inserted loxP sites flanking exon 1 and an adjacent neomycin resistance gene with another loxP site at the 3' end. The floxed neo was removed via cre-mediated recombination. (J:244504)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count