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The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. The coding sequences for optimized FLP recombinase was inserted at the transcriptional start site of the endogenous Dbh gene replacing 106 bps of the first exon; a single lox2722 (modified LoxP) site marks the former position of a floxed neomycin resistance cassette that was deleted by Cre-mediated recombination. The resulting allele is a knock-out of Dbh protein product but express Flpo recombinase under control of the Dbh gene. (J:251840)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
