Log In|Sign Up
EN
Transgene consists of the hCre-2A-eqFP650-2A-Thy1.1 cDNA fragment inserted immediately downstream of the Foxp3 ATG translational start site by homologous recombination into a 188-kb mouse BAC (from the C57BL/6 genome; clone RP23-143D8) carrying the intact Foxp3 gene was used. The CNS1 enhancer in Foxp3 gene was deleted by another round of homologous recombination. The modified BAC was purified and microinjected into the pronuclei of a (B6xB6D2) F1 mouse fertilized ovum to generate transgenic line of mice. Three founder mice were generated and screened for Thy1.1 and endogenous Foxp3 expression.The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:252233)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
