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CRISPR/Cas9-mediated gene editing was used to introduce five point mutations into the native mouse beta-actin gene, altering it to encode gamma-actin protein. In homozygous mice, no beta-actin protein is produced, and gamma-actin is expressed under the control of the endogenous beta-actin promoter. (J:256857)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
