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The coding sequence for farnesylated mCherry (mCherry-F, membrane bound form) was inserted in-frame at the alternative start site in exon 3 of the gene. Reduced expression of the full length wild type mRNA in the IO nucleus, as well as the retina, olfactory bulb, and hippocampus was observed. Homozygous mutant mice displayed no detectable wild type protein expression in the IO nucleus while membrane-associated mCherry-F expression was seen in cells that normally express the endogenous protein. (J:256160)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
