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Using four sgRNAs and CRISPR/Cas9 technology in C57BL/6 zygotes to delete exon 2, resulted in the creation of four mutant pups (No.7, 10, 22 and 26). Founder number 7 was used to establish a germ line. This allele represents a 146 bp deletion, which removes most of exon 2 and creates a frame shift and premature stop codon. (J:244081)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
