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A genomic fragment (8.4 kb) covering exons 10-12 was replaced with a 1.9-kb phosphoglycerate kinase-neomycin resistance (PGK-Neo) cassette. This mutation causes an reading frame shift and thereby generates a loss-of-function allele. Semi-quantitative RT-PCR and immunofluorescence staining confirmed absence of expression in the intestine of homozygous mutant mice. (J:243849)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
