A loxP site was inserted upstream of the transcriptional start site and a second loxP site was inserted downstream of exon 2. An FRT-site-flanked PGK-Neo cassette inserted adjacent to the second loxP site, and was removed via FLP-mediated recombination. (J:256576)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count