A loxP site was inserted upstream of exon 22. An FRT-flanked neomycin resistance cassette was inserted downsteam of exon 22. Flp-mediated recombination removed the selection cassette and left exon 22 floxed. (J:256217)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count