Log In|Sign Up
EN
The transgene consists of the CAG promoter consisting of a cytomegalovirus enhancer and a chicken beta-actin promoter, a loxP flanked chloramphenicol acetyl-transferase (cat) reporter gene with stop codons at the 3' end and human 15-lipoxygenase-1 cDNA. In the absence of Cre-recombination, the CAG promoter drives the expression of the cat reporter gene but not ALOX15. When Cre-mediated recombination removes the floxed cat reporter, CAG drives the expression of human ALOX15. Three lines were established: 1857, 1863, 1868. (J:114903)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
