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EN
A Velocigene cassette ZEN-Ub1 replaced a genomic region of size 16081bp between positions 134072572-134088652 of Chromosome 7 (Genome Build37). The hUBCpro-neo-p(A) cassette was removed via cre-mediated recombination. Western blot analysis confirmed complete loss of protein expression in various brain regions (hippocampus, cortex, cerebellum and midbrain) from homozygous mutant mice and a ~50% reduction in heterozygotes. (J:250125)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
