Log In|Sign Up
EN
LoxP sites were inserted upstream of exon 2 and downstream of exon 14 through homologous recombination. Cre-mediated recombination in ES cells resulted in the deletion of exons 2-14. The deletion resulted in the elimination of the N-deacetylase and N-sulfotransferase activities of the protein. RT-PCR analysis of cerebral RNA confirmed the absence of mRNA transcripts in homozygous mutant mice. (J:252046)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
