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Cre-mediated recombination of loxP sites surrounding exon 2, which includes part of the 5' UTR and codes for the N-terminal 280 of 2542 amino acids of the protein, resulted in the removal of this exon in the germline. Expression of the encoded protein was shown to be abolished by Western blot analysis of protein extracts derived from homozygous mutant mice. (J:251454)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
