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A lox5171 site was inserted upstream of exon 1. An F3 site flanked hygromycin resistance cassette with a 5' lox5171 site was inserted downstream of exon 3. The construct was injected into ES cells containing the Tex19.1tm2Ics allele. Flp-mediated recombination removed the hygro cassette. Cre-mediated recombination removed exons 1-3 containing the coding sequence. Western blot analysis confirmed the absence of protein expression in ES cells and testis. (J:243444)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
