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Plasmids encoding a signal guide RNA are designed to insert a point mutation in exon 4 of the gene. Exon 4 was modified to harbor a tyrosine to cytosine substitution at amino acid 198 (C198R), which corresponds to a C203R mutation commonly found in patients with Blue Cone Monochromacy. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
