A 1089-bp DNA fragment between nucleotides 25,289,972-25,291,060 on Chromosome 2 (Genome Build 38) containing the entire protein coding sequence was replaced by the ZEN-UB1 cassette, which contains the E. coli galactosidase gene (lacZ) and a loxP-flanked sequence comprising the promoter of the human ubiquitin C gene driving expression of neomycin phosphotransferase. The present allele was generated by Cre recombinase-mediated excision of the selection cassette. (J:136110)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count