This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GTAGAGCTTGGTAATGCAAG, GAATGATCATGACGTTTTCA, GCTACTGTCCTGAATACACG and GCCTCTCTTCCACAGACCCA, which resulted in a 454 bp deletion beginning at Chromosome 7 negative strand position 109,331,843 bp and ending after 109,331,390 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000205668 (exon 7) and 315 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 181 and early truncation 1 amino acid later. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count