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The transgene comprises the following elements: the bovine keratin 10 promoter, a rabbit beta-globin intron, a cDNA for the constitutively active isoform of the mouse Nfe2l2 gene which lacks sequence for the N-terminal Neh2 domain, and human growth hormone gene poly(A) features. Three mouse lines, with expression levels similar to or lower than the endogenous gene, were established after pronuclear injection of FVB/N fertilized oocytes. The pound # sign is used in the allele symbol because no line was specified. (J:160519)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
