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The transgene comprises the following elements: a beta-actin promoter, a loxP site flanked STOP cassette, the cDNA for the constitutively active isoform of the mouse Nfe2l2 gene which lacks sequence for the N-terminal Neh2 domain, an internal ribosomal entry site (IRES), and the EGFP fluorescent reporter gene. This is line 4 of five mouse lines with different integration sites that were established after pronuclear injection of FVB/N fertilized oocytes. The mouse gene (and the reporter) will only be expressed after deletion of the STOP cassette through Cre-mediated recombination. (J:160519)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
