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A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 5. The neo cassette was removed through subsequent flp-mediated recombination. Exons 2-5 were deleted through cre-mediated recombination by crossing these mice with mice carrying the Tg(rx3-icre)1Mjam allele. That allele shows leaky expression in the oocytes, thus creating some non-conditional null mouse lines i this crossing. (J:243503)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
