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A targeting construct was designed to insert a loxP-flanked neomycin (neo) resistance cassette upstream of exon 15 of the X-linked methyl-CpG binding domain protein 1 (Mbd1) gene. A 23 amino acid Tavi tag, allowing MBD2 protein to be biotinylated in the presence of E. coli biotin ligase, BirA, was introduced immediately upstream of Mbd1 stop codon. Breeding to B6.FVB-Tg(EIIa-cre)C5379Lmgd/J transgenic mice (Stock No. 003724) removed the neo cassette. (J:240794)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
