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DNA sequence comprising the beta-galactosidase (lacZ) reporter gene and a loxP site flanked neomycin resistance gene driven by human UBC and bacterial EM7 promoters, replaced a 32 kbp region of the target gene spanning exons 4 to 21. Severely reduced transcription from this knock-out allele was shown by qRT-PCR. No lacZ activity was detected by either qRT-PCR or enzymatic assays. (J:243171)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
