Tg(tetO-ERBB2*)5BKkw

Seven direct repeats of the tetracycline-operator (tetO) sequence drive inducible expression of the human gene with in-frame AYVM insertion at residue M774 (YVMA used because M774insAYVM and A775insYVMA lead to identical amino acid changes). Two founders were established: 26 (low copy number, high expression levels) and 5B (high copy numbers, low expression levels). (J:143874)