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A construct containing a floxed minigene cassette (made of 375 bp of intron 14, mouse Braf exons 15-19, 3 polyA sites and a synthetic polyadenylation signal) a mutated version of exon 15 where the TVKS motif was changed to AVKA, and an FRT flanked neo cassette was inserted replacing the endogenous exon 15. Flp mediated recombination removed the neo cassette. Cre-mediated recombination removed the floxed minigene resulting in production of a mutant transcript. The mutations of T599 and S602 to alanines blocks phosphorylation at these residues. (J:229687)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
