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The targeting vector is designed to insert, by site-directed mutagenesis, a point mutation (GAC to GCC) at nucleotide 419 followed by an FRT-flanked neomycin cassette downstream of exon 4. The mutation results in an alteration of the corresponding amino acid from aspartic acid to alanine (D140A) at codon 140. Flp-mediated recombination removed the FRT-flanked neo cassette. The mutation does not affect peroxidase activity, but does eliminate phospholipase A2 activity. (J:239138)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
