Log In|Sign Up
EN
LoxP sites were inserted into intron 15 and 16 and glutamic acid codon 446 (GAA) in exon 16 was changed to glutamine (CAA) (p.E446Q). This mutation is expected to disrupt the protein activity. The kanamycin-neomycin resistance gene cassette that was inserted into intron 15 was removed through subsequent Flp-mediated recombination. Cre-mediated recombination removed modified exon 16. (J:243488)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
