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Sequences encoding for the simian diphtheria toxin receptor (DTR) fused to EGFP and bGH polyA sequences downstream of a double-stop (ds) cassette consisting of a floxed STOP signal and an frt flanked nuclear bata-galactosidase (nlsLacZ) and STOP signal was inserted into Mapt locus. Endogenous Mapt promoter drives expression of nlsLacZ or DTR/EGFP fusion protein. Cre mediated removal of the first STOP signal is required for expression of nlsLacZ. Cre and flp mediated recombination are required to remove both STOP signals to allow for expression of the DTR/EGFP fusion protein. (J:227180)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
