The targeting vector is designed to insert a loxP site followed by an FRT-flanked neomycin resistance (neo) cassette, upstream of exon 6, and a second loxP site was inserted downstream of exon 6 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 6 floxed. (J:341591)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count