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EN
A substitution of serine by alanine at amino-acid position 81 (S81A), corresponding to the human variant of HRC with this substitution at position 96 (T286G) that is associated with higher risk of ventricular arrhythmias, was introduced in the gene. A frt flanked neo cassette was inserted upstream of the mutation and was removed via flp-mediated recombination. (J:243733)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
