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A portion of the part of the gene coding for the compaction region, one of the active domains of the protein, was replaced with synthetic sequence where 13 selected lysine and arginine codons had been changed to alanine codons. This was done through CRISPR/Cas9 endonuclease-assisted homologous recombination where the transgene vector, two sgRNAs and Cas9 mRNA were injected into C57BL/6 zygotes. The allele codes for a protein with redsuced activity. (J:242063)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
