The targeting vector contains an FRT-flanked neomycin cassette followed by a loxP site upstream of exon 6 and a second loxP site downstream of exon 6.Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed the floxed neo cassette. (J:243715)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count