Log In|Sign Up
EN
A loxP site was inserted into intron 40 and a second loxP site and an FRT site flanked neomycin resistance gene cassette was inserted into intron 41. The neo cassette was found to interfer with transcription from this locus, giving rise to a knockout-like phenotype. It was subsequently removed through flp-mediated recombination in the embryonic stem cells. This creates a conditional-ready allele with exon 41 floxed (exon numbering as in transcript model CCDS40219.1). (J:242077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
