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A vector containing the following elements was injected into pronuclei of the host embryos: mouse promoter, Kozak sequence, the mouse cDNA, 29 bp Myc tag, two stop codons, Kozak sequence and the human growth hormone 1 minigene. Zygotes were isolated from BTBR (Black and Tan Brachyury) females. BTBR mice are models for the study of type 2 diabetes (T2DM) and autism spectrum disorder (ASD) and carry the Disc1del, Itpr3tf and T+ alleles. The human gene confers high levels of expression of this allele. Expression of the mouse gene was confirmed by RT-PCR, but unintended expression of the human gene was also shown. Likewise, both the mouse and human proteins were detected. The pound symbol (#) is used when no line is specified. (J:227290)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
