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The murine alpha-myosin heavy chain promoter drives the expression of the mouse troponin I with an arginine to glycine substitution at residue 146 (R146G) in the inhibitory domain which corresponds to the R145G mutation in familial hypertrophic cardiomyopathy in humans. Four lines were generated and two, lines 121 and 133, were analyzed. RNA overexpression levels for line 121 is 1.2-fold higher compared to endogenous RNA. (J:243628)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
