Tg(Myh6-MYL2*E22K)4Dsc

The mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third drives the cardiac-specific expression of a mutated human myosin regulatory light chain 2 cDNA that contains an amino acid substitution of lysine for glutamic acid at position 22 (E22K, a familial hypertrophic cardiomyopathy-linked mutation). An N-terminal myc sequence was added to aid in identification of the human transgenic protein. Two lines were generated, L2 and L4. Line 4 is entered as the representative line. (J:101467)