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Using an sgRNA (5'-GCAAGACTGGCTTCAGGCCTG-3') targeting the exon 3 splice acceptor site with CRISPR/Cas9, an allele with a 12 bp deletion of that site was created. Exon 3 has high homology to the human ortholog and its splice site is conserved. Only one progeny was born. (J:241346)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
