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The mouse cardiac truncated protein lacking both the myosin and titin protein binding domains is under the control of the mouse alpha-myosin heavy chain promoter. Western blot analysis confirmed expression of the truncated protein. The truncated protein shows aberrant incorporation into sarcomeres. Five lines were generated: 21, 33, 31, 32, and 15. This is one of the high expressing lines, showing over 6-fold expression levels. (J:50237)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
