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The codons for serines 408 and 409 in exon 9 were mutated to alanine and a loxP and FRT flanked neo cassette was inserted upstream of the 5' end of exon 9 via homologous recombination. Cre-mediated recombination removed the neo cassette. Cell surface expression of this subunit is increased to 145% of wild-type without modifying total subunit expression levels. (J:228332)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
