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Cysteine to alanine mutations were inserted at position 609 and 612 (C609A and C612A; TGCACTCTATGT to GCTACTCTAGCT) in exon 7 and a floxed neo cassette was inserted at position chr10:18726067 (NCBI37/mm9) via homologous recombination. Cre mediated recombination removed the neo cassette. The mutations disrupt the structure of the ZnF4 ubiquitin binding motif. (J:228302)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
