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LoxP sites were inserted to flank exon 22, which encodes the majority of the RNase III domain. Loss of this exon would result in the generation of in-frame stop codons generated by frameshift mutations, likely to destabilize the resulting transcript. Flp mediated recombination removed an FRT-flanked neo that was included in the vector. Cre-mediated recombination removed exons 22. (J:243335)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
