A targeting vector containing iCre (codon-improved Cre recombinase), a polyadenylation sequence, and an FRT site flanked PGK-NEO cassette was inserted into the initiation codon site of exon 2 of the targeted gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:229096)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count