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The human gene ligated to a glycosylphosphatidylinositol (GPI) anchor is under the control of the alpha myosin heavy chain promoter. The GPI anchors the LPL to the cardiomyocyte surface. Northern blot analysis confirmed high expression of the transgene only in the heart. Hearts, but not post-heparin plasma, contains human lipoprotein lipase activity. Three lines were generated; 346, 357, and 358. (J:134550)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
