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EN
A p2lox targeting plasmid is designed to insert the human DUX4 ORF and 3' UTR followed by a poly A tail in front of a tetO promoter by exchanging it with the existing Cre recombinase ORF, using loxP and lox2272 sites. A non-functional neomycin resistance (neo) gene is placed downstream. This construct is inserted into a cassette exchange locus upstream of the Hprt gene using Inducible Cassette Exchange (ICE) recombination. (J:243630)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
