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The SUMO ligase activity of the gene was inactivated by introduction of mutations encoding C195S and H197A in intron 6 and an FRT flanked pgk-neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. In vitro auto-SUMOylation assays confirmed the absence of SUMO ligase activity. However, protein levels and the stability of SMC5/6 complexes are similar to wild-type protein. (J:227197)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
