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A c.419G>A mutation was engineered in exon 4, changing arginine codon 140 into a glutamine codon (p.Arg140Gln). This mutation is found in tumors from human accute myeloid leukemia (AML) patients. A loxP site flanked neomycin resistance gene and stop cassette was inserted into intron 3. This creates a conditional-ready null allele that expresses the mutated protein only after cre-mediated recombination. (J:241017)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
